Organic Chemistry Department, Faculty of Pharmacy, Sofia (BG)

Department of Organic Chemistry

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	Head of the Department Prof. Ivo C. Ivanov, D. Sc. (CV) Phone: (+ 359-2) 9236-533; Fax: (+ 359-2) 987-9874 E-mail:
Prof. I. C. Ivanov
Brief Historical Outline From 1942 to 1945 the organic chemistry lectures for the pharmacy students were delivered by the prominent Bulgarian scientist Academician Dimitar Ivanov (1894-1975; the inventor of the Ivanov reagents) who was then head of the Department of organic chemistry at the University of Sofia. In 1954 the curriculum for students of pharmacy with regard to the teaching in organic chemistry was oriented mainly towards the presentation of biologically active medicinal compounds. The course was then led by lecturers of the newly established Department of Pharmaceutical and Organic Chemistry headed by Prof. Dimitar Dalev. For some time he delivered lectures in both subjects.
	The first assistant professor in the Department of Organic Chemistry after 1954 was Damyan Danchev (1921-1995) who was appointed associate professor in 1966 and full professor of Organic Chemistry in 1975. Until 1986 he was head of the Department of Pharmaceutical and Organic Chemistry as well as of the Department of Organic Chemistry which was founded in January, 1982. A course in chemical-pharmaceutical technology and some of the organic chemistry lectures were also delivered by Associate Professor Lyuben Velichkov (1928-1998) until 1989. From 1986 till 1990 a part of the teaching staff was temporarily involved in a research group for applied organic synthesis. In 1990, Prof. Ivo C. Ivanov was elected as a head of the department. He delivers the lectures of organic chemistry (basic course) since 1989. Associate Prof. Elena G. Chalina performs the organic chemistry course with the extramural students. Associate Prof. Ilia Manolov performs the specialised course of Chemical-pharmaceutical technology.
Prof. D. Danchev
	Teaching Staff Full Professor: Dr. Ivo C. Ivanov Associate Professor: Dr. Elena G. Chalina	*Assistant Professors:* Dr. Piroshka B. Sulay Dr. Lyubomir D. Raev Dr. Rossen T. Buyukliev Dr. Violina Stoyanova Chem. Engineer Ginka R. Troanska Chem. Engineer Peter I. Vassilev Ph.D. student: Stancho Stanchev
Prof. E. Chalina
	Associate Professor: Dr. Ilia Manolov	Other Specialists Technicians: Snejana Alexandrova, Rayna Christova, Tsvetanka Nikolova, Stoyanka Stoyanova
Prof. I. Manolov

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Subjects and Duration of Courses

Core Subjects:

Organic Chemistry (basic course): III + IV semester (lectures - 90 h; seminars - 30 h; practicum - 150 h.)

Chemical-pharmaceutical technology (special course): IX semester (lectures - 30 h; practicum - 60 h.)

Click here to DOWNLOAD some lectures and the actual program of Organic Chemistry course (in Bulgarian).

Courses are offered at:

Undergraduate level (regular and extramural students)

Postgraduate level

Main Fields of Research

Synthesis of polycyclic N-and O-heterocyclic compounds with fused rings (derivatives of coumarin, pyran, pyridine, pyrimidine, 1,6-naphthyridine).

Synthesis, chemical and pharmacological studies of ether derivatives of 3-amino-1,2-propanediol as compounds with β-adrenoblocking activity.

Addition reactions of polyfunctional enamines to coumarin and coumarin derivatives; chemical transformations of the obtained adducts including cyclization to polycyclic systems with fused rings.

Synthesis and studies of 2-aminotetralin derivatives with expected adrenergic activity.

Isolation and chemical transformations of macrocyclic spermine alkaloids.

Reactivity of some polyfunctional enamines and their application to the synthesis of biologically active compounds.

Medical Orientation

Large-scale preparation of synthetic and/or naturally occurring compounds for pharmacological and/or biological experiments.

Development of new laboratory routes and procedures for the synthesis of known drugs.

International Links and Collaboration

Joint research project with the Pharmaceutical Institute of the Christian-Albrechts-University of Kiel, Germany.

Joint research agreement with the TAACF program - Southern Research Institute, Birmingham, Alabama (USA).

Collaboration with the Institute of Organic Chemistry, University of Stuttgart, Germany.

Collaboration with the School of Chemistry, University of Applied Sciences, Aalen, Germany.

Equipment

Instrument for nuclear magnetic resonance with Fourier transformation (FT-NMR) Bruker WP 100 (100 MHz);

Fourier transformation infrared (FTIR) spectrophotometer SHIMADZU FT-IR 8101 M.

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Last modified: 30.11.2007